human LATS2 shRNA silencing AAV

Name
AAV-h-LATS2-shRNA

Cat No
shAAV-213706

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human LATS2.

shAAV-213706

AAV-h-LATS2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LATS2 (large tumor suppressor kinase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

KPM

Description (Vector)

LATS2 encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

Gene ID

26524

Gene Name (Vector)

large tumor suppressor kinase 2

Gene Symbol

LATS2

HGNC ID

HGNC:6515

ORF Size (aa)

3264

ORF Size (bp)

3264 bp

RefSeq ID

NM_014572

RefSeq Synonyms

NM_014572, BC172545, BC156423,

Species

human

UniGene ID

Hs.78960

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.