human DTL Over-expression AAV

Name 
AAV-h-DTL
Cat No 
AAV-207370
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human DTL.

AAV-207370
AAV-h-DTL

Ready-to-use AAV expressing Human DTL (denticleless E3 ubiquitin protein ligase homolog). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CDT2; DCAF2; DDB1- and CUL4-associated factor 2; denticleless protein homolog; L2DTL; lethal(2) denticleless protein homolog; RAMP; RA-regulated nuclear matrix-associated protein; retinoic acid-regulated nuclear matrix-associated protein
Description (eCommerce)
DTL/CDT2 is a component of the CUL4A-DDB1 E3 ubiquitinating complex and plays a role in downregulating CDT1, an essential component of pre-replication complexes (Pre-RC) that ensures the genome is replicated only once per cycle. As part of the CUL4A-DDB1 E3 ligase complex DTL/CDT2 is also involved in the regulation of other proteins involved in the G2/M cell cycle checkpoint.
Gene ID
51514
Gene Name (eCommerce)
denticleless E3 ubiquitin protein ligase homolog
Gene Name (Vector)
denticleless E3 ubiquitin protein ligase homolog
Gene Symbol
DTL
HGNC ID
HGNC:30288
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2193
ORF Size (bp)
2193 bp
Protein Name (eCommerce)
Denticleless protein homolog
RefSeq ID
NM_016448
RefSeq Synonyms
NM_016448, NM_001286230, NM_001286229, BC033540, BC033297,
Research Areas
Cell Cycle,Cytoskeleton,DNA Damage/Repair,DNA Replication,Ubiquitination
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
DTL/CDT2 is a component of the CUL4A-DDB1 E3 ubiquitinating complex and plays a role in downregulating CDT1, an essential component of pre-replication complexes (Pre-RC) that ensures the genome is replicated only once per cycle. As part of the CUL4A-DDB1 E3 ligase complex DTL/CDT2 is also involved in the regulation of other proteins involved in the G2/M cell cycle checkpoint.
UniGene ID
Hs.656473
UniProt ID (eCommerce)
Q9NZJ0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.