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human KLF5 shRNA silencing AAV

Name 
AAV-h-KLF5-shRNA
Cat No 
shAAV-213192
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human KLF5.

shAAV-213192
AAV-h-KLF5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KLF5 (Kruppel like factor 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
basic transcription element binding protein 2; Basic transcription element-binding protein 2; BTEB2; BTE-binding protein 2; CKLF; colon krueppel-like factor; colon kruppel-like factor; epididymis secretory sperm binding protein; GC box binding protein 2; GC-box-binding protein 2; IKLF; intestinal Kruppel-like factor; intestinal-enriched krueppel-like factor; intestinal-enriched kruppel-like factor; Klf5C isoform; Krueppel-like factor 5; Kruppel-like factor 5 (intestinal); transcription factor BTEB2
Description (eCommerce)
KLF5 a member of the Kruppel-like factor subfamily of zinc finger proteins. KLF5 is a transcriptional activator that acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. [taken from NCBI Entrez Gene (Gene ID: 688)].
Description (Vector)
KLF5 encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.
Gene ID
688
Gene Name (eCommerce)
Kruppel like factor 5
Gene Name (Vector)
Kruppel like factor 5
Gene Symbol
KLF5
HGNC ID
HGNC:6349
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1374
ORF Size (bp)
1374 bp
Protein Name (eCommerce)
Krueppel-like factor 5
RefSeq ID
NM_001730
RefSeq Synonyms
NM_001730, NM_001286818, BC042131, BC007695,
Research Areas
Angiogenesis,Golgi Apparatus,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,transcription_translation
Species
human
Target Sentence
KLF5 a member of the Kruppel-like factor subfamily of zinc finger proteins. KLF5 is a transcriptional activator that acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. [taken from NCBI Entrez Gene (Gene ID: 688)].
UniGene ID
Hs.508234
UniProt ID (eCommerce)
Q13887

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.