human KIAA1949 shRNA silencing AAV

Name 
AAV-h-KIAA1949-shRNA
Cat No 
shAAV-213053
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PPP1R18.

shAAV-213053
AAV-h-KIAA1949-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PPP1R18 (protein phosphatase 1 regulatory subunit 18). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
HKMT1098; KIAA1949; phostensin; protein phosphatase 1 F-actin cytoskeleton targeting subunit; Protein phosphatase 1 F-actin cytoskeleton-targeting subunit; Protein phosphatase 1 regulatory subunit 18
Description (eCommerce)
PPP1R18 may target protein phosphatase 1 to F-actin cytoskeleton [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6NYC8].
Description (Vector)
Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) cytoskeleton (Kao et al., 2007 (PubMed 17374523)).(supplied by OMIM, Mar 2008)
Gene ID
170954
Gene Name (eCommerce)
protein phosphatase 1 regulatory subunit 18
Gene Name (Vector)
protein phosphatase 1 regulatory subunit 18
Gene Symbol
PPP1R18
HGNC ID
HGNC:29413
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1842
ORF Size (bp)
1842 bp
Protein Name (eCommerce)
Phostensin
RefSeq ID
NM_001134870
RefSeq Synonyms
NM_133471, NM_001134870, BC066644,
Research Areas
Cytoskeleton,Kinase/Phosphatase
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
PPP1R18 may target protein phosphatase 1 to F-actin cytoskeleton [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6NYC8].
UniGene ID
Hs.696054
UniProt ID (eCommerce)
Q6NYC8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.