human KIAA0776 shRNA silencing AAV

Name 
AAV-h-KIAA0776-shRNA
Cat No 
shAAV-212948
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human UFL1.

shAAV-212948
AAV-h-KIAA0776-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human UFL1 (UFM1 specific ligase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
85
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
E3 UFM1-protein ligase 1; E3 UFM1-protein transferase 1; KIAA0776; LZAP-binding protein; Maxer; NLBP; novel LZAP-binding protein; RCAD; regulator of C53/LZAP and DDRGK1; Regulator of CDK5RAP3 and DDRGK1
Description (eCommerce)
UFM1-specific ligase 1 (UFL1) is and E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. UFL1 may act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O94874].
Gene ID
23376
Gene Name (eCommerce)
UFM1 specific ligase 1
Gene Name (Vector)
UFM1 specific ligase 1
Gene Symbol
UFL1
HGNC ID
HGNC:23039
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2385
ORF Size (bp)
2385 bp
Protein Name (eCommerce)
E3 UFM1-protein ligase 1
RefSeq ID
NM_015323
RefSeq Synonyms
NM_015323, BC036379, BC028608,
Research Areas
Cancer,Tumor Suppressors/Oncoproteins,Ubiquitination
Research Areas (Faceted)
cancer,cell_biology
Species
human
Target Sentence
UFM1-specific ligase 1 (UFL1) is and E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. UFL1 may act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O94874].
UniGene ID
Hs.149367
UniProt ID (eCommerce)
O94874

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.