human KCNQ1 shRNA silencing AAV

Name
AAV-h-KCNQ1-shRNA

Cat No
shAAV-212771

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human KCNQ1.

shAAV-212771

AAV-h-KCNQ1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KCNQ1 (potassium voltage-gated channel subfamily Q member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1; LQT; LQT1; RWS; SQT2; WRS

Description (Vector)

KCNQ1 encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. KCNQ1 exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. KCNQ1 is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.

Gene ID

3784

Gene Name (Vector)

potassium voltage-gated channel subfamily Q member 1

Gene Symbol

KCNQ1

HGNC ID

HGNC:6294

ORF Size (aa)

1650

ORF Size (bp)

1650 bp

RefSeq ID

NM_000218

RefSeq Synonyms

NM_181798, NM_000218, BC113545, BC111847,

Species

human

UniGene ID

Hs.95162

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.