human JUP shRNA silencing AAV

Name 
AAV-h-JUP-shRNA
Cat No 
shAAV-212611
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human JUP.

shAAV-212611
AAV-h-JUP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human JUP (junction plakoglobin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; CTNNG; desmoplakin III; desmoplakin-3; DP3; DPIII; junction plakoglobin; PDGB; PKGB
Description (eCommerce)
Plakoglobin (gamma-catenin) is a member of the catenin family of proteins. It bears an armadillo repeat motif and plays a role in cell signaling; but unlike beta-catenenin, which plays a major role in the Wnt signaling pathway, plakoglobin is thought to act as a tumor/metastasis suppressor. Plakoglobin also functions as a junctional plaque protein and forms complexes with cadherins and desmosomal cadherins.
Description (Vector)
JUP encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.
Gene ID
3728
Gene Name (eCommerce)
junction plakoglobin
Gene Name (Vector)
junction plakoglobin
Gene Symbol
JUP
HGNC ID
HGNC:6207
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2238
ORF Size (bp)
2238 bp
Protein Name (eCommerce)
Junction plakoglobin
RefSeq ID
NM_002230
RefSeq Synonyms
NM_021991, NM_002230, BC011865,
Research Areas
Apoptosis,Cancer,Cardiac Development,Cardiology,Cardiomyopathy,Cardiovascular,Cytoskeleton,EGFR Signaling,Leukemia,Neurobiology,Neurodevelopment,Signal Transduction,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,Translational Control,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Plakoglobin (gamma-catenin) is a member of the catenin family of proteins. It bears an armadillo repeat motif and plays a role in cell signaling; but unlike beta-catenenin, which plays a major role in the Wnt signaling pathway, plakoglobin is thought to act as a tumor/metastasis suppressor. Plakoglobin also functions as a junctional plaque protein and forms complexes with cadherins and desmosomal cadherins.
UniGene ID
Hs.514174
UniProt ID (eCommerce)
P14923

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.