human JAK1 shRNA silencing AAV

Name
AAV-h-JAK1-shRNA

Cat No
shAAV-212572

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human JAK1.

shAAV-212572

AAV-h-JAK1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human JAK1 (Janus kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

JAK1A; JAK1B; JTK3

Description (Vector)

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

Gene ID

3716

Gene Name (Vector)

Janus kinase 1

Gene Symbol

JAK1

HGNC ID

HGNC:6190

ORF Size (aa)

3465

ORF Size (bp)

3465 bp

RefSeq ID

NM_002227

RefSeq Synonyms

NM_002227, NM_001321857, NM_001321856, NM_001321855, NM_001321854, NM_001321853, NM_001321852, NM_001320923, BC132729,

Species

human

UniGene ID

Hs.207538

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.