human JAK1 Adenovirus
Category: Adenovirus > Over-Expression
Cat. No: ADV-212572
Availability:
3-5 weeks
Name:
Ad-h-JAK1
This is an Adenovirus expressing Human JAK1.
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Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- CMV
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- JAK1
- Gene Name
- Janus kinase 1
- Gene ID
- 3716
- Gene Synonyms
- JAK1A; JAK1B; JTK3
- ORF Size
- 3465 bp
- RefSeq#
- BC132729
- Gene Description
- Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.
- UniGene ID
- Hs.207538
- HGNC ID
- HGNC:6190
Related Products
Product | Cat No. |
---|---|
Ad-JAK1 | 1485 |
AAV-h-JAK1 | AAV-212572 |
AAV-h-JAK1-shRNA | shAAV-212572 |
Ad-h-JAK1-shRNA | shADV-212572 |
Control Products
Product | Cat No. |
---|---|
Ad-CMV-Luc | 1000 |
Ad-GFP | 1060 |
Ad-CMV-b-Gal | 1080 |
Ad-Null | 1240 |
Ad-CMV-Null | 1300 |
Ad-RFP | 1660 |
Ad-CFP | 1766 |
Ad-mCherry | 1767 |
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