human ITPR3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ITPR3.
shAAV-212550
AAV-h-ITPR3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
inositol 1,4,5-triphosphate receptor, type 3; inositol 1,4,5-trisphosphate receptor type 3; insP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R; IP3R 3; IP3R3; Type 3 inositol 1,4,5-trisphosphate receptor; type 3 InsP3 receptor
Description (eCommerce)
IP3R3 (inositol 1,4,5-triphosphate receptor type 3) is an intracellular calcium release channel that mediates calcium release from the endoplasmic reticulum. There are 3 mammalian IP3R receptors: IP3R1, IP3R2, and IP3R3. IP3R3 has been shown to play a role in olfactory mucus secretion and in the taste perception of sweet, savory (umami), and bitter substances.
Description (Vector)
ITPR3 encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.
Gene ID
3710
Gene Name (eCommerce)
inositol 1,4,5-trisphosphate receptor type 3
Gene Name (Vector)
inositol 1,4,5-trisphosphate receptor type 3
Gene Symbol
ITPR3
HGNC ID
HGNC:6182
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
8016
ORF Size (bp)
8016 bp
Protein Name (eCommerce)
Inositol 1,4,5-trisphosphate receptor type 3
RefSeq ID
NM_002224
RefSeq Synonyms
NM_002224, BC172406,
Research Areas
Alzheimer's Disease,B-cell Receptor Signaling,Cancer,Cardiology,Cardiovascular,Cell Cycle,EGFR Signaling,EGFR Signaling in Cancer,Estrogen Signaling,Fc Receptor Signaling,FGF Signaling,GnRH Signaling,GPCR Signaling,Immunology,Innate Immunity,Kinase/Phosphatase,Meiosis,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,NF-kB Signaling,NGF Signaling,PDGF Signaling,Signal Transduction,T-cell Receptor Signaling,Transport,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
IP3R3 (inositol 1,4,5-triphosphate receptor type 3) is an intracellular calcium release channel that mediates calcium release from the endoplasmic reticulum. There are 3 mammalian IP3R receptors: IP3R1, IP3R2, and IP3R3. IP3R3 has been shown to play a role in olfactory mucus secretion and in the taste perception of sweet, savory (umami), and bitter substances.
UniGene ID
Hs.65758
UniProt ID (eCommerce)
Q14573
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.