human ITGB2 shRNA silencing AAV

Name
AAV-h-ITGB2-shRNA

Cat No
shAAV-212506

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ITGB2.

shAAV-212506

AAV-h-ITGB2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ITGB2 (integrin subunit beta 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7

Description (Vector)

The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.

Gene ID

3689

Gene Name (Vector)

integrin subunit beta 2

Gene Symbol

ITGB2

HGNC ID

HGNC:6155

ORF Size (aa)

2310

ORF Size (bp)

2310 bp

RefSeq ID

NM_000211

RefSeq Synonyms

NM_001303238, NM_001127491, NM_000211, BC005861,

Species

human

UniGene ID

Hs.375957

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.