human ITGB1 shRNA silencing AAV

Name 
AAV-h-ITGB1-shRNA
Cat No 
shAAV-212500
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ITGB1.

shAAV-212500
AAV-h-ITGB1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ITGB1 (integrin subunit beta 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD29; CD29; Fibronectin receptor subunit beta; FNRB; glycoprotein IIa; GPIIA; integrin beta 1; integrin beta-1; integrin VLA-4 beta subunit; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); MDF2; MSK12; very late activation protein, beta polypeptide; VLA-4 subunit beta; VLAB; VLA-BETA
Description (eCommerce)
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells [taken from NCBI Entrez Gene (Gene ID: 3688)].
Description (Vector)
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
Gene ID
3688
Gene Name (eCommerce)
integrin subunit beta 1
Gene Name (Vector)
integrin subunit beta 1
Gene Symbol
ITGB1
HGNC ID
HGNC:6153
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2397
ORF Size (bp)
2397 bp
Protein Name (eCommerce)
Integrin beta-1
RefSeq ID
NM_002211
RefSeq Synonyms
NM_133376, NM_033668, NM_002211, BC020057,
Research Areas
Angiogenesis,Apoptosis,Axon Guidance,Cancer,Cardiac Development,Cardiology,Cardiomyopathy,Cardiovascular,Cell Cycle,Cytoskeleton,EGFR Signaling,HGF Signaling,Host-Virus Interactions,Immunology,Lung Cancer,MAPK Signaling,Neurobiology,Neurodevelopment,PI3K/Akt Signaling,Prolactin Signaling,Rho Signaling,RNA Processing,Signal Transduction,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells [taken from NCBI Entrez Gene (Gene ID: 3688)].
UniGene ID
Hs.643813
UniProt ID (eCommerce)
P05556

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.