human IKBKB shRNA silencing AAV

I-kappa-B kinase 2; I-kappa-B-kinase beta; IkBKB; IKK2; IKKB; IKK-B; IKK-beta; IMD15; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKB; nuclear factor NF-kappa-B inhibitor kinase beta

IKK-beta (Inhibitor of nuclear factor kappa B kinase subunit beta) is one of three subunits that comprise the IKK complex. The IKK complex consists of two catalytic subunits, IKK-alpha and IKK-beta, and a regulatory subunit IKK-gamma/NEMO. As a kinase, IKK functions to phosphorylate members of the NF-kappa B inhibitor proteins, the I-kappa B proteins. Phosphorylation of I-kappa B proteins results in the ubiquitination and degradation of I kappa B and the release and translocation of the NF-kappa B transcription factor to the nucleus where it may function to activate a vast number of genes.

IKBKB phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene.

3551

inhibitor of nuclear factor kappa B kinase subunit beta

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

IKBKB

HGNC:5960

9606.0

1263

1263 bp

Inhibitor of nuclear factor kappa-B kinase subunit beta

NM_001556

NM_001556, NM_001242778, NM_001190720, BC108694,

Apoptosis,B-cell Receptor Signaling,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,CD40 Signaling,CD95/FAS Signaling,Cell Cycle,Cytokine Signaling,EPO Signaling,Fc Receptor Signaling,FoxO Signaling,Gene Expression,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leptin Signaling,Leukemia,Lung Cancer,MAPK Signaling,MicroRNAs in Cancer,mTOR Signaling,Neurobiology,NF-kB Signaling,NGF Signaling,PI3K/Akt Signaling,Prostate Cancer,RANKL-RANK Signaling,Response to Virus,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,Toll-like Receptor Signaling,TRAIL Signaling,Transcription Factor/Regulator,TSH Signaling,TWEAK Signaling,VEGF Signaling

cancer,cardiovascular,cell_biology,cell_cycle,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation

human

IKK-beta (Inhibitor of nuclear factor kappa B kinase subunit beta) is one of three subunits that comprise the IKK complex. The IKK complex consists of two catalytic subunits, IKK-alpha and IKK-beta, and a regulatory subunit IKK-gamma/NEMO. As a kinase, IKK functions to phosphorylate members of the NF-kappa B inhibitor proteins, the I-kappa B proteins. Phosphorylation of I-kappa B proteins results in the ubiquitination and degradation of I kappa B and the release and translocation of the NF-kappa B transcription factor to the nucleus where it may function to activate a vast number of genes.

Hs.597664

O14920