human IGFBP3 shRNA silencing AAV

Name
AAV-h-IGFBP3-shRNA

Cat No
shAAV-211932

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human IGFBP3.

shAAV-211932

AAV-h-IGFBP3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IGFBP3 (insulin like growth factor binding protein 3). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BP-53; IBP3

Description (Vector)

IGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene ID

3486

Gene Name (Vector)

insulin like growth factor binding protein 3

Gene Symbol

IGFBP3

HGNC ID

HGNC:5472

ORF Size (aa)

876

ORF Size (bp)

876 bp

RefSeq ID

NM_000598

RefSeq Synonyms

NM_001013398, NM_000598, BC064987, BC018962, BC000013,

Species

human

UniGene ID

Hs.450230

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.