human HTRA2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human HTRA2.
shAAV-211714
AAV-h-HTRA2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human HTRA2 (HtrA serine peptidase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
OMI; PARK13; PRSS25;
Description (Vector)
HTRA2 encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
Gene ID
27429
Gene Name (Vector)
HtrA serine peptidase 2
Gene Symbol
HTRA2
HGNC ID
HGNC:14348
ORF Size (aa)
1377
ORF Size (bp)
1377 bp
RefSeq ID
NM_013247
RefSeq Synonyms
NM_145074, NM_013247, NM_001321728, NM_001321727, BC000096,
Species
human
UniGene ID
Hs.716372
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.