human HSPB8 shRNA silencing AAV

Name
AAV-h-HSPB8-shRNA

Cat No
shAAV-211660

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human HSPB8.

shAAV-211660

AAV-h-HSPB8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HSPB8 (heat shock protein family B (small) member 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CMT2L; DHMN2; E2IG1; H11; HMN2; HMN2A; HSP22

Description (Vector)

HSPB8 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.

Gene ID

26353

Gene Name (Vector)

heat shock protein family B (small) member 8

Gene Symbol

HSPB8

HGNC ID

HGNC:30171

ORF Size (aa)

591

RefSeq ID

NM_014365

RefSeq Synonyms

NM_014365, BC002673,

Species

human

UniGene ID

Hs.400095

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.