human HR shRNA silencing AAV

Name
AAV-h-HR-shRNA

Cat No
shAAV-211511

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human HR.

shAAV-211511

AAV-h-HR-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HR (HR, lysine demethylase and nuclear receptor corepressor). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1

Description (Vector)

HR encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by multiple regulatory ORFs that exist upstream of the primary ORF. Mutations in one of these upstream ORFs, U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

55806

Gene Name (Vector)

HR, lysine demethylase and nuclear receptor corepressor

Gene Symbol

HGNC ID

HGNC:5172

ORF Size (aa)

3570

ORF Size (bp)

3570 bp

RefSeq ID

NM_005144

RefSeq Synonyms

NM_018411, NM_005144, BC067128,

Species

human

UniGene ID

Hs.272367

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.