human HR Adenovirus

Name
Ad-h-HR

Cat No
ADV-211511

Availability
4-5 weeks

This is an Adenovirus expressing Human HR.

ADV-211511

Ad-h-HR

Ready-to-use Adenovirus expressing Human HR (HR, lysine demethylase and nuclear receptor corepressor). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1

Description (Vector)

HR encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by multiple regulatory ORFs that exist upstream of the primary ORF. Mutations in one of these upstream ORFs, U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

55806

Gene Name (Vector)

HR, lysine demethylase and nuclear receptor corepressor

Gene Symbol

HGNC ID

HGNC:5172

ORF Size (aa)

3570

ORF Size (bp)

3570 bp

RefSeq ID

NM_005144

RefSeq Synonyms

NM_018411, NM_005144, BC067128,

Species

human

UniGene ID

Hs.272367

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.