human HGS shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human HGS.
shAAV-210998
AAV-h-HGS-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human HGS (hepatocyte growth factor-regulated tyrosine kinase substrate). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
hepatocyte growth factor-regulated tyrosine kinase substrate; HRS; human growth factor-regulated tyrosine kinase substrate; protein pp110
Description (eCommerce)
Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) is an endosomal protein that participates in the trafficking and sorting of proteins to degradative or recycling pathways. HRS can bind ubiquitin directly and plays a key role in sorting ubiquitinated proteins to lysosomes. HRS has also been demonstrated to regulate protein sorting independent of its ubiquitin-binding motif.
Description (Vector)
HGS regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.
Gene ID
9146
Gene Name (eCommerce)
hepatocyte growth factor-regulated tyrosine kinase substrate
Gene Name (Vector)
hepatocyte growth factor-regulated tyrosine kinase substrate
Gene Symbol
HGS
HGNC ID
HGNC:4897
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2334
ORF Size (bp)
2334 bp
Protein Name (eCommerce)
Hepatocyte growth factor-regulated tyrosine kinase substrate
RefSeq ID
NM_004712
RefSeq Synonyms
NM_004712, BC003565,
Research Areas
Cancer,EGFR Signaling,EGFR Signaling in Cancer,HGF Signaling,Immunology,JAK-STAT Signaling,Lysosomal Transport,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,Translational Control,Transport,Ubiquitination,VEGF Signaling,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) is an endosomal protein that participates in the trafficking and sorting of proteins to degradative or recycling pathways. HRS can bind ubiquitin directly and plays a key role in sorting ubiquitinated proteins to lysosomes. HRS has also been demonstrated to regulate protein sorting independent of its ubiquitin-binding motif.
UniGene ID
Hs.514590
UniProt ID (eCommerce)
O14964
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.