human HFE shRNA silencing AAV

Name
AAV-h-HFE-shRNA

Cat No
shAAV-210991

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human HFE.

shAAV-210991

AAV-h-HFE-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HFE (hemochromatosis). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HFE1; HH; HLA-H; MVCD7; TFQTL2

Description (Vector)

HFE is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.

Gene ID

3077

Gene Name (Vector)

hemochromatosis

Gene Symbol

HFE

HGNC ID

HGNC:4886

ORF Size (aa)

1047

ORF Size (bp)

1047 bp

RefSeq ID

NM_000410

RefSeq Synonyms

NM_139011, NM_139010, NM_139009, NM_139008, NM_139007, NM_139006, NM_139004, NM_139003, NM_001300749, NM_000410, BC117203, BC117201, BC074721,

Species

human

UniGene ID

Hs.233325

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.