human GSTA1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GSTA1.
shAAV-210592
AAV-h-GSTA1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GSTA1 (glutathione S-transferase alpha 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GST-epsilon; GST2; GSTA1-1; GTH1
Description (Vector)
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.
Gene ID
2938
Gene Name (Vector)
glutathione S-transferase alpha 1
Gene Symbol
GSTA1
HGNC ID
HGNC:4626
ORF Size (aa)
669
ORF Size (bp)
669 bp
RefSeq ID
NM_145740
RefSeq Synonyms
NM_145740, NM_001319059, BC110891, BC053578,
Species
human
UniGene ID
Hs.446309
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.