human GRN shRNA silencing AAV

Name
AAV-h-GRN-shRNA

Cat No
shAAV-210559

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human GRN.

shAAV-210559

AAV-h-GRN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GRN (granulin precursor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CLN11; GEP; GP88; PCDGF; PEPI; PGRN

Description (Vector)

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene ID

2896

Gene Name (Vector)

granulin precursor

Gene Symbol

GRN

HGNC ID

HGNC:4601

ORF Size (aa)

1317

ORF Size (bp)

1317 bp

RefSeq ID

NM_002087

RefSeq Synonyms

NM_002087, BC010577, BC000324,

Species

human

UniGene ID

Hs.514220

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.