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human GRK6 shRNA silencing AAV

Name 
AAV-h-GRK6-shRNA
Cat No 
shAAV-210541
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human GRK6.

shAAV-210541
AAV-h-GRK6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GRK6 (G protein-coupled receptor kinase 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6; GPRK6
Description (eCommerce)
G protein-coupled receptor kinase 6 (GRK6) is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation [taken from NCBI Entrez Gene (Gene ID: 2870)].
Description (Vector)
GRK6 encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.
Gene ID
2870
Gene Name (eCommerce)
G protein-coupled receptor kinase 6
Gene Name (Vector)
G protein-coupled receptor kinase 6
Gene Symbol
GRK6
HGNC ID
HGNC:4545
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1770
ORF Size (bp)
1770 bp
Protein Name (eCommerce)
G protein-coupled receptor kinase 6
RefSeq ID
NM_002082
RefSeq Synonyms
NM_002082, NM_001004106, NM_001004105, BC017272, BC009277,
Research Areas
Cardiology,Cardiovascular,EPO Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Neurobiology,Signal Transduction,VEGF Signaling,Wnt Signaling
Research Areas (Faceted)
cardiovascular,cell_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
G protein-coupled receptor kinase 6 (GRK6) is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation [taken from NCBI Entrez Gene (Gene ID: 2870)].
UniGene ID
Hs.235116
UniProt ID (eCommerce)
P43250

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.