human GPN1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GPN1.
shAAV-210243
AAV-h-GPN1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GPN1 (GPN-loop GTPase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATP(GTP)-binding protein; ATPBD1A; GPN-loop GTPase 1; MBD2-interacting protein; MBDIN; NTPBP; RNA polymerase II associated protein 4; RNAPII-associated protein 4; RPAP4; XAB1; XPA binding protein 1, GTPase; XPA-binding protein 1
Description (eCommerce)
GPN-loop GTPase 1 (GPN1) forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. GPN1 may be involved in nuclear localization of XPAÂ [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9HCN4].
Description (Vector)
GPN1 encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described.
Gene ID
11321
Gene Name (eCommerce)
GPN-loop GTPase 1
Gene Name (Vector)
GPN-loop GTPase 1
Gene Symbol
GPN1
HGNC ID
HGNC:17030
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1125
ORF Size (bp)
1125 bp
Protein Name (eCommerce)
GPN-loop GTPase 1
RefSeq ID
NM_007266
RefSeq Synonyms
NM_007266, NM_001145049, NM_001145048, NM_001145047, BC007451,
Research Areas
Transport
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
GPN-loop GTPase 1 (GPN1) forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. GPN1 may be involved in nuclear localization of XPAÂ [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9HCN4].
UniGene ID
Hs.18259
UniProt ID (eCommerce)
Q9HCN4
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.