human GPC3 shRNA silencing AAV

Name
AAV-h-GPC3-shRNA

Cat No
shAAV-210219

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human GPC3.

shAAV-210219

AAV-h-GPC3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GPC3 (glypican 3). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DGSX; GTR2-2; MXR7; OCI-5; SDYS; SGB; SGBS; SGBS1

Description (Vector)

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.

Gene ID

2719

Gene Name (Vector)

glypican 3

Gene Symbol

GPC3

HGNC ID

HGNC:4451

ORF Size (aa)

1743

ORF Size (bp)

1743 bp

RefSeq ID

NM_004484

RefSeq Synonyms

NM_004484, NM_001164619, NM_001164618, NM_001164617, BC035972,

Species

human

UniGene ID

Hs.644108

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.