human GMPS shRNA silencing AAV

Name 
AAV-h-GMPS-shRNA
Cat No 
shAAV-210058
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human GMPS.

shAAV-210058
AAV-h-GMPS-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GMPS (guanine monophosphate synthase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
75
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GATD7; glutamine amidotransferase; GMP synthase; GMP synthase glutamine-hydrolyzing; GMP synthetase; guanine monophosphate synthetase; guanosine 5'-monophosphate synthase; MLL/GMPS fusion protein; testicular tissue protein Li 82
Description (eCommerce)
Guanine monophosphate (GMP) synthase is an enzyme involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P49915].
Description (Vector)
In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.
Gene ID
8833
Gene Name (eCommerce)
guanine monophosphate synthase
Gene Name (Vector)
guanine monophosphate synthase
Gene Symbol
GMPS
HGNC ID
HGNC:4378
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2082
ORF Size (bp)
2082 bp
Protein Name (eCommerce)
GMP synthase [glutamine-hydrolyzing]
RefSeq ID
NM_003875
RefSeq Synonyms
NM_003875, BC012178,
Research Areas
Cancer,Metabolism/Metabolic Process
Research Areas (Faceted)
cancer,cell_biology,metabolism
Species
human
Target Sentence
Guanine monophosphate (GMP) synthase is an enzyme involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P49915].
UniGene ID
Hs.591314
UniProt ID (eCommerce)
P49915

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.