human GIGYF2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GIGYF2.
shAAV-209876
AAV-h-GIGYF2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GIGYF2 (GRB10 interacting GYF protein 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GRB10-interacting GYF protein 2; GYF2; PARK11; Parkinson disease (autosomal recessive, early onset) 11; PERQ amino acid rich, with GYF domain 3; PERQ amino acid-rich with GYF domain-containing protein 2; PERQ2; PERQ3; TNRC15; trinucleotide repeat-containing gene 15 protein
Description (eCommerce)
GRB10 interacting GYF protein 2 (GIGYF2) interacts with GRB10 and may be involved in the regulation of tyrosine kinase receptor signaling. The GIGYF2 contains CAG repeats, and the encoded protein contains stretches of glutamine and glutamic acid residues. Defects in the GIGYF2 gene are a cause of Parkinson disease type 11 (PARK11) [taken from NCBI Entrez Gene (Gene ID: 26058)].
Description (Vector)
GIGYF2 interacts with GRB10 and may be involved in the regulation of tyrosine kinase receptor signaling. This gene contains CAG repeats, and the encoded protein contains stretches glutamine and glutamic acid residues. Defects in this gene are a cause of Parkinson disease type 11 (PARK11). Multiple transcript variants encoding several different isoforms have been found for this gene.
Gene ID
26058
Gene Name (eCommerce)
GRB10 interacting GYF protein 2
Gene Name (Vector)
GRB10 interacting GYF protein 2
Gene Symbol
GIGYF2
HGNC ID
HGNC:11960
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3963
ORF Size (bp)
3963 bp
Protein Name (eCommerce)
PERQ amino acid-rich with GYF domain-containing protein 2
RefSeq ID
NM_015575
RefSeq Synonyms
NM_015575, NM_001103148, NM_001103147, NM_001103146, BC146775, BC136251,
Research Areas
Apoptosis,Cell Cycle,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,Neurodevelopment,Parkinson's Disease,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
GRB10 interacting GYF protein 2 (GIGYF2) interacts with GRB10 and may be involved in the regulation of tyrosine kinase receptor signaling. The GIGYF2 contains CAG repeats, and the encoded protein contains stretches of glutamine and glutamic acid residues. Defects in the GIGYF2 gene are a cause of Parkinson disease type 11 (PARK11) [taken from NCBI Entrez Gene (Gene ID: 26058)].
UniGene ID
Hs.565319
UniProt ID (eCommerce)
Q6Y7W6
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.