human FXN shRNA silencing AAV

Name
AAV-h-FXN-shRNA

Cat No
shAAV-209435

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human FXN.

shAAV-209435

AAV-h-FXN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FXN (frataxin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CyaY; FA; FARR; FRDA; X25

Description (Vector)

This nuclear gene encodes a mitochondrial protein which belongs to FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in Friedreich ataxia. Alternative splicing results in multiple transcript variants.

Gene ID

2395

Gene Name (Vector)

frataxin

Gene Symbol

FXN

HGNC ID

HGNC:3951

ORF Size (aa)

633

RefSeq ID

NM_000144

RefSeq Synonyms

NM_181425, NM_001161706, NM_000144, BC048097, BC023633,

Species

human

UniGene ID

Hs.29978

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.