human FOXP2 shRNA silencing AAV

Name
AAV-h-FOXP2-shRNA

Cat No
shAAV-209279

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human FOXP2.

shAAV-209279

AAV-h-FOXP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FOXP2 (forkhead box P2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CAGH44; SPCH1; TNRC10

Description (Vector)

FOXP2 encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. FOXP2 is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.

Gene ID

93986

Gene Name (Vector)

forkhead box P2

Gene Symbol

FOXP2

HGNC ID

HGNC:13875

ORF Size (aa)

2145

ORF Size (bp)

2145 bp

RefSeq ID

NM_014491

RefSeq Synonyms

NM_148900, NM_148899, NM_148898, NM_014491, NM_001172767, NM_001172766, BC143867, BC143866, BC126104,

Species

human

UniGene ID

Hs.656280

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.