human FOXN3 shRNA silencing AAV

Name
AAV-h-FOXN3-shRNA

Cat No
shAAV-209269

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human FOXN3.

shAAV-209269

AAV-h-FOXN3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FOXN3 (forkhead box N3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C14orf116; checkpoint suppressor 1; CHES1; forkhead box protein N3; PRO1635

Description (eCommerce)

Forkhead box protein N3 (FOXN3) functions as a transcriptional repressor. FOXN3 is also called checkpoint suppressor 1 (CHES1) and may be involved in DNA damage-inducible cell cycle arrests (checkpoints).

Description (Vector)

FOXN3 is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.

Gene ID

1112

Gene Name (eCommerce)

forkhead box N3

Gene Name (Vector)

forkhead box N3

Gene Symbol

FOXN3

HGNC ID

HGNC:1928

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1407

ORF Size (bp)

1407 bp

Protein Name (eCommerce)

Forkhead box protein N3

RefSeq ID

NM_005197

RefSeq Synonyms

NM_005197, NM_001085471, BC010460, BC007506,

Research Areas

Cell Cycle,DNA Damage/Repair,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,cell_cycle,genetics,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.621371

UniProt ID (eCommerce)

O00409

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.