human FOLH1 shRNA silencing AAV

Name
AAV-h-FOLH1-shRNA

Cat No
shAAV-209214

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human FOLH1.

shAAV-209214

AAV-h-FOLH1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FOLH1 (folate hydrolase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

FGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA

Description (Vector)

FOLH1 encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. FOLH1 likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.

Gene ID

2346

Gene Name (Vector)

folate hydrolase 1

Gene Symbol

FOLH1

HGNC ID

HGNC:3788

ORF Size (aa)

2160

ORF Size (bp)

2160 bp

RefSeq ID

NM_004476

RefSeq Synonyms

NM_004476, NM_001193473, NM_001193472, NM_001193471, NM_001014986, BC025672,

Species

human

UniGene ID

Hs.654487

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.