human FBXW2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human FBXW2.
shAAV-208834
AAV-h-FBXW2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human FBXW2 (F-box and WD repeat domain containing 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
FBW2; Fwd2; Md6
Description (Vector)
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
Gene ID
26190
Gene Name (Vector)
F-box and WD repeat domain containing 2
Gene Symbol
FBXW2
HGNC ID
HGNC:13608
ORF Size (aa)
1365
ORF Size (bp)
1365 bp
RefSeq ID
NM_012164
RefSeq Synonyms
NM_012164, BC110334, BC018738,
Species
human
UniGene ID
Hs.494985
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.