human RHEB shRNA silencing AAV

Name
AAV-h-RHEB-shRNA

Cat No
shAAV-208542

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human RHEB.

shAAV-208542

AAV-h-RHEB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RHEB (Ras homolog enriched in brain). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

RHEB2

Description (Vector)

RHEB is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.

Gene ID

6009

Gene Name (Vector)

Ras homolog enriched in brain

Gene Symbol

RHEB

HGNC ID

HGNC:10011

ORF Size (aa)

555

RefSeq ID

NM_005614

RefSeq Synonyms

NM_005614, BC107705, BC066307, BC016155,

Species

human

UniGene ID

Hs.283521

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.