human EXOSC6 shRNA silencing AAV

Name
AAV-h-EXOSC6-shRNA

Cat No
shAAV-208194

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human EXOSC6.

shAAV-208194

AAV-h-EXOSC6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EXOSC6 (exosome component 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EAP4; hMtr3p; MTR3; Mtr3p; p11

Description (Vector)

EXOSC6 product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.

Gene ID

118460

Gene Name (Vector)

exosome component 6

Gene Symbol

EXOSC6

HGNC ID

HGNC:19055

ORF Size (aa)

819

ORF Size (bp)

819 bp

RefSeq ID

NM_058219

RefSeq Synonyms

NM_058219, BC052252,

Species

human

UniGene ID

Hs.660633

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.