human EVPL shRNA silencing AAV

Name
AAV-h-EVPL-shRNA

Cat No
shAAV-208164

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human EVPL.

shAAV-208164

AAV-h-EVPL-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EVPL (envoplakin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; envoplakin; EVPK; p210

Description (eCommerce)

Envoplakin is a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. The gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against Envoplakin [taken from NCBI Entrez Gene (Gene ID: 2125)].

Gene ID

2125

Gene Name (eCommerce)

envoplakin

Gene Name (Vector)

envoplakin

Gene Symbol

EVPL

HGNC ID

HGNC:3503

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

6168

ORF Size (bp)

6168 bp

Protein Name (eCommerce)

Envoplakin

RefSeq ID

NM_001988

RefSeq Synonyms

NM_001988, NM_001320747, BC143814, BC126105, BC126103,

Research Areas

Cytoskeleton

Research Areas (Faceted)

cell_biology

Species

human

Target Sentence

Envoplakin is a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. The gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against Envoplakin [taken from NCBI Entrez Gene (Gene ID: 2125)].

UniGene ID

Hs.500635

UniProt ID (eCommerce)

Q92817

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.