human EVI1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MECOM.
shAAV-208156
AAV-h-EVI1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MECOM (MDS1 and EVI1 complex locus). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AML1-EVI-1; EVI1; KMT8E; MDS1; MDS1-EVI1; PRDM3; RUSAT2
Description (Vector)
MECOM is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.
Gene ID
2122
Gene Name (Vector)
MDS1 and EVI1 complex locus
Gene Symbol
MECOM
HGNC ID
HGNC:3498
ORF Size (aa)
3159
ORF Size (bp)
3159 bp
RefSeq ID
NM_005241
RefSeq Synonyms
NM_005241, NM_004991, NM_001205194, NM_001164000, NM_001163999, NM_001105078, NM_001105077, BC143952, BC143951, BC130520,
Species
human
UniGene ID
Hs.656395
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.