human ESR1 shRNA silencing AAV

Name 
AAV-h-ESR1-shRNA
Cat No 
shAAV-208114
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ESR1.

shAAV-208114
AAV-h-ESR1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ESR1 (estrogen receptor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
E2 receptor alpha; ER; Era; ER-alpha; ESR; ESRA; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; ESTRR; NR3A1; nuclear receptor subfamily 3 group A member 1; oestrogen receptor alpha
Description (eCommerce)
The estrogen receptor (ER) is the steroid-hormone nuclear receptor that binds estrogen and functions to activate genes involved in a variety of biological processes. Two forms of the ER, ER alpha and ER beta, are encoded by independent genes, and each plays different roles in gene regulation. Additional variants of ER beta have also been reported; these include ERb2, ERb3, ERb4, and ERb5. All forms of the ER have the ability to heterodimerize with each other. Differences in localization and concentrations as well as heterodimerization among the variants may serve to achieve distinct cell and tissue responses. ER alpha generally functions as an activator of transcription while ER beta functions as a repressor.
Description (Vector)
ESR1 encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
Gene ID
2099
Gene Name (eCommerce)
estrogen receptor 1
Gene Name (Vector)
estrogen receptor 1
Gene Symbol
ESR1
HGNC ID
HGNC:3467
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1788
ORF Size (bp)
1788 bp
Protein Name (eCommerce)
Estrogen receptor
RefSeq ID
NM_000125
RefSeq Synonyms
NM_001328100, NM_001291241, NM_001291230, NM_001122742, NM_001122741, NM_001122740, NM_000125, BC128574, BC128573,
Research Areas
Apoptosis,Breast Cancer,Cancer,Cell Cycle,Chromatin Remodeling,Estrogen Signaling,Gene Expression,Golgi Apparatus,Leptin Signaling,LKB1 Signaling,Neurobiology,Neurodegeneration,NF-kB Signaling,Parkinson's Disease,Prolactin Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
The estrogen receptor (ER) is the steroid-hormone nuclear receptor that binds estrogen and functions to activate genes involved in a variety of biological processes. Two forms of the ER, ER alpha and ER beta, are encoded by independent genes, and each plays different roles in gene regulation. Additional variants of ER beta have also been reported; these include ERb2, ERb3, ERb4, and ERb5. All forms of the ER have the ability to heterodimerize with each other. Differences in localization and concentrations as well as heterodimerization among the variants may serve to achieve distinct cell and tissue responses. ER alpha generally functions as an activator of transcription while ER beta functions as a repressor.
UniGene ID
Hs.208124
UniProt ID (eCommerce)
P03372

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.