human ERG shRNA silencing AAV

Name
AAV-h-ERG-shRNA

Cat No
shAAV-208068

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ERG.

shAAV-208068

AAV-h-ERG-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ERG (ERG, ETS transcription factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

erg-3; p55

Description (Vector)

ERG encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. ERG is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene ID

2078

Gene Name (Vector)

ERG, ETS transcription factor

Gene Symbol

ERG

HGNC ID

HGNC:3446

ORF Size (aa)

1440

ORF Size (bp)

1440 bp

RefSeq ID

NM_004449

RefSeq Synonyms

NM_182918, NM_004449, NM_001331025, NM_001291391, NM_001243432, NM_001243429, NM_001243428, NM_001136155, NM_001136154, BC040168,

Species

human

UniGene ID

Hs.473819

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.