human DYNLL1 shRNA silencing AAV

Name
AAV-h-DYNLL1-shRNA

Cat No
shAAV-207469

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human DYNLL1.

shAAV-207469

AAV-h-DYNLL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DYNLL1 (dynein light chain LC8-type 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DLC1; DLC8; DNCL1; DNCLC1; hdlc1; LC8; LC8a; PIN

Description (Vector)

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.

Gene ID

8655

Gene Name (Vector)

dynein light chain LC8-type 1

Gene Symbol

DYNLL1

HGNC ID

HGNC:15476

ORF Size (aa)

270

RefSeq ID

NM_003746

RefSeq Synonyms

NM_003746, NM_001037495, NM_001037494, BC104245, BC104244, BC100289,

Species

human

UniGene ID

Hs.5120

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.