human DDR1 shRNA silencing AAV

Name
AAV-h-DDR1-shRNA

Cat No
shAAV-206715

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human DDR1.

shAAV-206715

AAV-h-DDR1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DDR1 (discoidin domain receptor tyrosine kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE

Description (Vector)

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene ID

780

Gene Name (Vector)

discoidin domain receptor tyrosine kinase 1

Gene Symbol

DDR1

HGNC ID

HGNC:2730

ORF Size (aa)

2631

ORF Size (bp)

2631 bp

RefSeq ID

NM_001954

RefSeq Synonyms

NM_013994, NM_013993, NM_001954, NM_001297654, NM_001297653, NM_001297652, NM_001202523, NM_001202522, NM_001202521, BC070070, BC013400, BC008716,

Species

human

UniGene ID

Hs.631988

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.