human DBN1 shRNA silencing AAV

Name 
AAV-h-DBN1-shRNA
Cat No 
shAAV-206622
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human DBN1.

shAAV-206622
AAV-h-DBN1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DBN1 (drebrin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
D0S117E; developmentally-regulated brain protein; drebrin; drebrin A; drebrin E; drebrin E2
Description (eCommerce)
Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. It is required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q16643].
Description (Vector)
DBN1 is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.
Gene ID
1627
Gene Name (eCommerce)
drebrin 1
Gene Name (Vector)
drebrin 1
Gene Symbol
DBN1
HGNC ID
HGNC:2695
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1950
ORF Size (bp)
1950 bp
Protein Name (eCommerce)
Drebrin
RefSeq ID
NM_004395
RefSeq Synonyms
NM_080881, NM_004395, BC007567, BC007281, BC000283,
Research Areas
Cytoskeleton,Neurobiology,Neurodevelopment,Neurogenesis
Research Areas (Faceted)
cell_biology,neurobiology,developmental_biology
Species
human
Target Sentence
Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. It is required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q16643].
UniGene ID
Hs.130316
UniProt ID (eCommerce)
Q16643

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.