human DAND5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DAND5.
shAAV-206583
AAV-h-DAND5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DAND5 (DAN domain BMP antagonist family member 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CER2; CERL2; CKTSF1B3; COCO; CRL2; DANTE; GREM3; SP1
Description (Vector)
DAND5 encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.
Gene ID
199699
Gene Name (Vector)
DAN domain BMP antagonist family member 5
Gene Symbol
DAND5
HGNC ID
HGNC:26780
ORF Size (aa)
570
ORF Size (bp)
570 bp
RefSeq ID
NM_152654
RefSeq Synonyms
NM_152654, BC113476, BC101800,
Species
human
UniGene ID
Hs.331981
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.