human DAAM1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DAAM1.
shAAV-206560
AAV-h-DAAM1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DAAM1 (dishevelled associated activator of morphogenesis 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins.
Gene ID
23002
Gene Name (Vector)
dishevelled associated activator of morphogenesis 1
Gene Symbol
DAAM1
HGNC ID
HGNC:18142
ORF Size (aa)
3207
ORF Size (bp)
3207 bp
RefSeq ID
NM_014992
RefSeq Synonyms
NM_014992, NM_001270520, BC064999, BC038428,
Species
human
UniGene ID
Hs.654934
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.