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human PDE11A shRNA silencing AAV

Name 
AAV-h-PDE11A-shRNA
Cat No 
shAAV-218459
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PDE11A.

shAAV-218459
AAV-h-PDE11A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDE11A (phosphodiesterase 11A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
PPNAD2
Description (Vector)
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
50940
Gene Name (Vector)
phosphodiesterase 11A
Gene Symbol
PDE11A
HGNC ID
HGNC:8773
ORF Size (aa)
2805
ORF Size (bp)
2805 bp
RefSeq ID
NM_016953
RefSeq Synonyms
NM_016953, NM_001077358, NM_001077197, NM_001077196, BC114431, BC112393,
Species
human
UniGene ID
Hs.570273

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.