human CYP2E1 shRNA silencing AAV

Name
AAV-h-CYP2E1-shRNA

Cat No
shAAV-206493

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CYP2E1.

shAAV-206493

AAV-h-CYP2E1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CYP2E1 (cytochrome P450 family 2 subfamily E member 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CPE1; CYP2E; P450-J; P450C2E

Description (Vector)

CYP2E1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

Gene ID

1571

Gene Name (Vector)

cytochrome P450 family 2 subfamily E member 1

Gene Symbol

CYP2E1

HGNC ID

HGNC:2631

ORF Size (aa)

1482

ORF Size (bp)

1482 bp

RefSeq ID

NM_000773

RefSeq Synonyms

NM_000773, BC067435, BC067433,

Species

human

UniGene ID

Hs.12907

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.