human CYP27A1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CYP27A1.
shAAV-206468
AAV-h-CYP27A1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CYP27A1 (cytochrome P450 family 27 subfamily A member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CP27; CTX; CYP27
Description (Vector)
CYP27A1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease.
Gene ID
1593
Gene Name (Vector)
cytochrome P450 family 27 subfamily A member 1
Gene Symbol
CYP27A1
HGNC ID
HGNC:2605
ORF Size (aa)
1596
ORF Size (bp)
1596 bp
RefSeq ID
NM_000784
RefSeq Synonyms
NM_000784, BC051851, BC040430,
Species
human
UniGene ID
Hs.516700
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.