human CTSC shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CTSC.
shAAV-206266
AAV-h-CTSC-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CTSC (cathepsin C). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CPPI; DPP-I; DPP1; DPPI; HMS; JP; JPD; PALS; PDON1; PLS
Description (Vector)
CTSC, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
1075
Gene Name (Vector)
cathepsin C
Gene Symbol
CTSC
HGNC ID
HGNC:2528
ORF Size (aa)
411
RefSeq ID
NM_001814
RefSeq Synonyms
NM_148170, NM_001814, NM_001114173, BC146692,
Species
human
UniGene ID
Hs.706874
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.