human CST3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CST3.
shAAV-206173
AAV-h-CST3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CST3 (cystatin C). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ARMD11; HEL-S-2
Description (Vector)
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease.
Gene ID
1471
Gene Name (Vector)
cystatin C
Gene Symbol
CST3
HGNC ID
HGNC:2475
ORF Size (aa)
441
RefSeq ID
NM_000099
RefSeq Synonyms
NM_001288614, NM_000099, BC110305, BC013083,
Species
human
UniGene ID
Hs.304682
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.