human CSK shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CSK.
shAAV-206125
AAV-h-CSK-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CSK (c-src tyrosine kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CSK, non-receptor tyrosine kinase; C-Src kinase; c-src tyrosine kinase; protein-tyrosine kinase CYL; tyrosine-protein kinase CSK
Description (eCommerce)
C-Src kinase (CSK) is a non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. CSK suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCKÂ [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P41240].
Gene ID
1445
Gene Name (eCommerce)
C-terminal Src kinase
Gene Name (Vector)
c-src tyrosine kinase
Gene Symbol
CSK
HGNC ID
HGNC:2444
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1353
ORF Size (bp)
1353 bp
Protein Name (eCommerce)
Tyrosine-protein kinase CSK
RefSeq ID
NM_004383
RefSeq Synonyms
NM_004383, NM_001127190, BC106073, BC104875, BC104847,
Research Areas
Angiogenesis,B-cell Receptor Signaling,Cancer,Cytoskeleton,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Golgi Apparatus,Hypoxia,Immunology,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Lung Cancer,PDGF Signaling,Signal Transduction,T-cell Receptor Signaling,VEGF Signaling
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,immunology,signal_transduction
Species
human
Target Sentence
C-Src kinase (CSK) is a non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. CSK suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCKÂ [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P41240].
UniGene ID
Hs.77793
UniProt ID (eCommerce)
P41240
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.