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human CRKRS shRNA silencing AAV

Name 
AAV-h-CRKRS-shRNA
Cat No 
shAAV-206022
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CDK12.

shAAV-206022
AAV-h-CRKRS-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CDK12 (cyclin dependent kinase 12). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Cdc2-related kinase, arginine/serine-rich; CDC2-related protein kinase 7; cell division cycle 2-related protein kinase 7; cell division protein kinase 12; CRK7; CRKR; CRKRS; cyclin-dependent kinase 12; hCDK12
Description (eCommerce)
CrkRS (Cdc2-related kinase, arginine/serine-rich) is a Cdc-2 related kinase that contains an arginine- and serine-rich (SR) domain and has recently been reported to interact with cyclin L1 and L2. Since it has been discovered that CrkRs pairs with a cyclin partner, it has also been given the name CDK12. CrkRs localizes to nuclear speckles and immunoprecipitates with RNA polymerse II and the SF2/ASF splicing factor and is proposed to play a role in the regulation of alternative splicing.
Gene ID
51755
Gene Name (eCommerce)
cyclin dependent kinase 12
Gene Name (Vector)
cyclin dependent kinase 12
Gene Symbol
CDK12
HGNC ID
HGNC:24224
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4446
ORF Size (bp)
4446 bp
Protein Name (eCommerce)
Cyclin-dependent kinase 12
RefSeq ID
NM_016507
RefSeq Synonyms
NM_016507, NM_015083, BC150265, BC140854,
Research Areas
Kinase/Phosphatase,mRNA Processing,mRNA Splicing,RNA Processing
Research Areas (Faceted)
cell_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
CrkRS (Cdc2-related kinase, arginine/serine-rich) is a Cdc-2 related kinase that contains an arginine- and serine-rich (SR) domain and has recently been reported to interact with cyclin L1 and L2. Since it has been discovered that CrkRs pairs with a cyclin partner, it has also been given the name CDK12. CrkRs localizes to nuclear speckles and immunoprecipitates with RNA polymerse II and the SF2/ASF splicing factor and is proposed to play a role in the regulation of alternative splicing.
UniGene ID
Hs.416108
UniProt ID (eCommerce)
Q9NYV4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.